O-020 What is the recovery time for sperm parameters in men who have suffered a mild Covid-19 infection?

Abstract Study question What is the time required in men who have suffered a mild Covid-19 infection, for seminal parameters to be restored pre-Covid values? Summary answer The effect of infection on concentration and sperm motility clearly confirmed maintained over time, at least beyond 100 days. known already Although several studies been performed SARS-CoV-2 reproductive health short term vs. healthy controls, negative has demonstrated, there scarcity data showing degree which virus affects semen one group patients after coronavirus compared before infection. Moreover, are no conclusive regarding long-term effects parameters. design, size, duration This prospective study was carried out 6 centers between February 2020 October 2022 including 45 male with diagnosis COVID-19. For each (volume, count, active total motility, normal morphology, vitality) standardized index calculated by dividing value parameter from subsequent analysis that same individual prior Participants/materials, setting, methods median age participants 31 years, proving absence relationship any analyzed. post-Covid test 17 516 days elapsed both samples 238 affectation studied, setting as cut-off point. Main results role chance There were significant differences COVID-19 terms volume, concentration, progressive vitality decreased significantly (p < 0,05) pre-infection values. Morphology not affected. count most affected parameter. Half individuals (median) obtained second sample less than 57% initial one. Considering spermatogenesis, subjects separated into two groups: those first it later. No found groups U Mann-Withney test. Using Wilcoxon paired samples, demonstrated deleterious only does improve but becomes more late analysis, hundred Limitations, reasons caution It should mentioned impairment may due direct virus. likely additional factors contribute decrease, whose identity currently unknown. Wider implications findings present revealed impacts various quality even Further efforts made long-time reproduction. Trial registration number Not Applicable